Sour Sensation

Researchers have found some of the major players in the detection of sour taste.

Pucker up! CREDIT: BRANDON DILBECK
By | Posted October 20, 2006
Posted in: Featured, Life Science
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Biting into a lemon will make your lips pucker—but when you mix its juice with sugar, water, and ice, you get a tasty beverage. Researchers have now uncovered cells and a protein that let mammals taste these tart treats, according to several recent studies.

The most definitive study appeared in the August 24 edition of the journal Nature, and its findings support earlier evidence that different tastes are monitored by distinct populations of cells rather than common cells attuned to all tastes.

Taste “is really one of the last sensory systems to be understood,” said Andrew Spielman, director of graduate studies in oral biology at New York University’s College of Dentistry, who did not participate in the studies. Identifying the players in the detection of taste is “a key contribution to the field.”

Sour is one of five basic tastes that animals use to learn about the quality of their food. Detecting sourness, which is an indication of acidity, is one way animals avoid eating substances that might be harmful. The sour taste of spoiled milk, for example, is a warning sign that it might contain microorganisms that could cause sickness if ingested.

“It’s not appealing, and for good reason,” said John DeSimone, a professor of physiology at Virginia Commonwealth University, who is not affiliated with the studies. Sour taste “is a mechanism that says ‘don’t ingest large quantities of acid’ because it’s likely to be bad for you.”

Researchers used to think that individual cells on the tongue could sense more than one taste. But later work by Charles Zuker, the head of the Nature study, showed that three tastes—sweet, bitter, and umami (savory)—are sensed by different cells. Some researchers suspected that salty and sour taste might act the same way.

The new studies on this subject appeared within several months of one another. The first, published in July in the Journal of Neurochemistry identified two proteins that are present in taste cells different from those used to detect sweet, sour, and savory. Another study, appearing in early August in the Proceedings of the National Academy of Sciences, found that those proteins respond to different acids.

But the last study, appearing in Nature this past August, was most extensive and its findings most definitive, according to DeSimone.

The researchers first identified one of the same proteins mentioned in the former studies. Then they engineered mice so that they were missing the cells that express that protein. The mice could sense all tastes except for sour, which allowed the researchers to conclude that those missing cells must be responsible for sensing sour taste.

Zuker’s team also found that the protein involved in sensing sour substances also exists in a set of neurons in the spinal cord and seems to play a role in monitoring pH—a measure of acidity—in the cerebrospinal fluid.

“It’s a wonderful example of Darwinian evolution at its best, where you use the same player in multiple places because it does the job so well,” said Zuker.

The recent findings could have implications for medicine. Understanding the basic mechanisms of taste—such as how the sour sensor works—is essential to treating people with taste disorders, according to Spielman. People who suffer a persistent sense of sourness in the mouth, for example, could benefit from treatment that blocks the sour sensor.

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  1. It’s interesting then that there is a wide array of children’s candy that is sour. It’s difficult to reconcile ‘sour as a warning’ with ‘sour as a delicious treat for kids’, as biologically, kids would need the most warning to learn to stay away from harmful foods.

    Rupal, October 20, 2006 at 6:09 pm
  2. Well, rrruuPAL. You raise a good point. As one of the researchers with whom I spoke said, sometimes sour isn’t such a terrible taste when mixed with other flavors–like sweet stuff (Sour Patch Kids are coated in sugar, for example). But you do have to wonder–if sourness is masked too much by another taste, could you end up ingesting too much acid because the “warning signal” has been subdued?

    RockMonkey, October 21, 2006 at 11:43 am
  3. Sweet or Sour? Sometimes there’s just no accounting for taste. Like relationships….you might find someone just so amazing, funny, smart, beautiful…that you can’t stop thinking about them….but things don’t quite fall into place, you make a mistake, or you’re just not the right person for that moment in time….leaving behind that sour taste of disappointment that only time can wash away.

    Jay, October 23, 2006 at 7:37 pm
  4. I see an analogy with the joy of sour candy to the thrill of riding a rollercoaster or watching a horror movie. The adrenaline rush is intended to help you run from danger or land on your feet, but for some reason we find it fun.

    Ryan, October 24, 2006 at 4:49 pm
  5. Some say that if you brush your tongue too often your taste buds lose their acute senses. Is there any truth to this Ms. Leibach? According to a lil’ smarty on the Tonight Show, the tongue is like a shag carpet. He says to brush it well, or else we’ll smell you from across the room. And that will make anyone seem unattractive. Is there a hidden evolutionary element at play here? Oral hygiene v. Sense of taste. (And of course, I have no idea what I’m talking about)

    BFro, October 26, 2006 at 2:15 pm
  6. Hmm. Are you asking if oral hygiene developed as a means to prevent the dulling of our sense of taste? I must look into the matter; perhaps we can continue this conversation in another setting, Mr. B. Fro.

    Julie, October 28, 2006 at 12:16 pm
  7. Hey, I took that picture of the lemon drops! I never expected anyone to use it like this! Cool! But for the record, the lemon drops in that picture aren’t really very sour.

    Brandon Dilbeck, November 15, 2006 at 12:32 am
  8. I’d like to know what causes the mouth to pucker in the first place. Someone said it was because some molecules or cells weren’t compatible with those found in the mouth. I really wished I had listened better, but I was distracted by my child.

    Noelle, March 27, 2007 at 6:11 am
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