Alcoholism after gastric bypass: Is it in your mind or gut?

Scientists have competing ideas for why gastric bypass patients show higher rates of alcohol abuse post-surgery

Alcoholism after gastric bypass: Is it in your mind or gut?
As researchers scramble to find explanations for alcoholism after gastric bypass surgery, many doctors still don’t know to warn patients about the risk. [Image credit: Flickr User Faisal Akram]

In 2009, Jackie Kim received a gastric bypass that shrunk her stomach and rerouted part of her small intestine. Within a year, she had lost 180 pounds and felt great.

Then her troubles with alcohol set in. It started with ordering wine in place of dessert at dinner. “At first I thought, ‘This is great, I don’t have to sit at the table twiddling my fork while everyone else is eating their crème brûlée,’” recalled Kim, a 44-year-old medical consultant living in St. Louis, Missouri.

But soon the occasional glass of wine turned into much more.

Kim spent the next two years fighting addiction. “Lots of scary stuff happened during those years,” she said. She regularly drank alone at home, two bottles of wine at a time. Before long, she was hiding bottles from her husband, driving while drunk, blacking out and discovering injuries she didn’t remember getting.

Her story is not uncommon. In 2012, a large study published in the Journal of the American Medical Association reported that the percentage of patients abusing alcohol increased from 7.6 percent before surgery to 9.6 percent two years after surgery — that’s potentially an additional 2,000 alcoholics each year in the United States. Since then, a growing body of evidence has corroborated these findings. The longest-running study suggests the effect persists even a decade after surgery.

Still, many patients today are unaware of the risk of alcoholism when they get a gastric bypass, and scientists themselves are not completely sure why the risk exists. One early theory was addiction transfer, which suggested that people might adopt new addictions after weight-loss surgery because they can no longer fulfill their food addictions. But more recent evidence suggests there may be an anatomical explanation: specific metabolic and hormonal changes triggered by gastric bypass that leave patients especially vulnerable to alcoholism but not other addictions. It’s also possible that both explanations are right — or neither.

“Whether it’s addiction transfer or something else going on, we really don’t know at this point,” said James Mitchell, a doctor and professor of neuroscience at the University of North Dakota. What’s certain, he said, is that the high rates of alcoholism in patients who have had a gastric bypass operation cannot be attributed to chance.

Doctors have long touted gastric bypass surgery as the gold standard for weight-loss operations. Of the 200,000 bariatric procedures performed in the United States each year, roughly 80 percent are gastric bypass surgeries. Research shows the surgery not only causes weight loss — 90 percent of gastric bypass patients keep off 50 percent of their extra weight even a decade after surgery — but also resolves related illnesses such as type 2 diabetes, heart disease and cancer, leading to a 40 percent overall reduction in mortality for gastric bypass patients.

But alcoholism could be a dark consequence of the surgery for some patients — even if no one is sure why.

The explanation of addiction transfer assumes that people who overeat are often predisposed to addiction. Researchers have reported addiction transfer in many forms — a recovering alcoholic might start chain-smoking, for instance. But the general idea is often contested, partly because it can be difficult to pinpoint the roots of addiction: some argue it is physiological, while others insist it is driven by psychology.

One physiological explanation for addiction, first described by a neuroscientist at the University of Florida named Kenneth Blum, is a blunted response to dopamine, a chemical that gets released in our brains when we perform high-reward activities such as eating, having sex, doing drugs and listening to music. Dopamine not only helps us register pleasure from these activities, it also motivates us to repeat them over and over again in search of more pleasure.

In 1990, Blum found a correlation between alcoholism and a genetic deficiency in dopamine-binding receptors in the brain, called D2 receptors. People with compromised D2 receptors seek higher thrills to satisfy their reward cravings than people with normal D2 receptors, Blum believes. He predicts that gastric bypass patients with a D2 deficiency turn to other high-reward activities, such as drinking alcohol, because they can’t binge eat with a constricted stomach.

Still, most scientists attribute addiction to a combination of genetic and environmental factors. Blaming addiction on a single gene is too simplistic, said Lance Dodes, a psychiatrist based in Boston who has written three books on the topic, including one called Breaking Addiction. Dodes believes addiction has a psychological basis. He argues that consuming a substance or behaving compulsively provides an outlet for people who feel otherwise unable to take direct action in their lives. Many of his alcoholic patients, he said, start feeling better the moment they decide to take a drink — not when the alcohol actually enters their bodies.

Addictions can be interchangeable because they are a psychological response to feeling trapped, said Dodes. “We call them separate addictions, but they’re really just one mechanism.”

But one major problem with Blum’s and Dodes’s ideas is that there’s little evidence of higher alcoholism rates after a different common bariatric surgery: gastric banding. Also known as lap banding, this surgery installs an inflatable belt around the stomach to constrict it. Unlike gastric bypass, banding does not permanently alter the stomach’s architecture.

The difference between the two surgeries suggests that alcohol abuse is related to structural changes from gastric bypass, said Alexis Conason, a New York City psychologist and researcher.

In 2012, Conason published a study in JAMA Surgery that found a significant increase in alcohol use for patients after gastric bypass, but not gastric banding. The study also found no significant increase in patients’ use of other drugs, including cigarettes, or compulsive behaviors such as gambling. “If it were addiction transfer, we’d be seeing it across the board,” Conason said.

Researchers have proposed a few physiological explanations for increased alcoholism specifically after gastric bypass. Some believe it’s due to changes in alcohol metabolism, since alcohol enters the bloodstream more quickly in a smaller stomach. A 2011 study from surgeons at Stanford University found that six months after surgery, gastric bypass patients reached higher blood alcohol levels more quickly than they did before surgery. This type of fast and high peak often characterizes addictive drugs, said North Dakota’s Mitchell. Cocaine and heroin, for example, both produce brief, intense rushes that leave users wanting more.

But it’s also possible that increased alcohol dependence has nothing to do with alcohol absorption in the stomach. Recently, a team of researchers led by neuroscientists at the Pennsylvania State University College of Medicine found that rats that had been given gastric bypasses developed a higher dependence on alcohol. Here’s the twist: the effect held even when the rats were given alcohol intravenously instead of orally. The authors concluded that alcohol abuse after gastric bypass could very well occur independently of how quickly alcohol passes from the gut to the bloodstream.

Instead, anatomical changes to the stomach might impact patients’ dopamine response, the Penn State researchers suggested. Some scientists have found that gastric bypass surgery can alter the signaling of D2 receptors. The mechanism for this is unclear, although preliminary research has identified altered patterns of gene expression in areas of the brain that process dopamine. Other researchers suggest that appetite-mediating gut hormones play a role, particularly those that affect dopamine signaling, such as insulin, leptin and grehlin. Scientists have shown that leptin and grehlin levels change after gastric bypass surgery, and both hormones are known to modulate alcohol consumption.

It’s also possible the explanation is not so clear-cut. Conason admits that researchers can’t completely write off addiction transfer, and there might be other reasons why alcoholism is more prevalent than other addictions. For instance, gastric bypass patients may simply be more likely to drink alcohol than take other drugs, which are less socially acceptable.

The risk of alcohol abuse is serious, Mitchell said, but it is one of many considerations for gastric bypass candidates. Particularly for people facing life-threatening conditions such as diabetes or heart disease, the possibility of alcohol abuse might not be strong enough for patients to actually forgo the surgery.

Even so, Mitchell and most of his colleagues agree that doctors need to strongly communicate the risk of alcohol abuse to patients before surgery. In many cases, including Jackie Kim’s, doctors don’t highlight the risk at all.

After years of counseling and seeing her addiction wreak havoc on her relationships and physical health, Kim reached a breaking point. She hasn’t touched a drink in more than two years. “But it wasn’t easy,” Kim said of her hard-fought recovery. She knows that others also might not have been coached on the risks, so she mentors patients who have had the surgery and posts in bariatric support groups online.

Kim believes that being aware of the problem would have made all the difference for her. “I experienced a lot of anger with my surgeons afterwards for not doing a better job educating me,” she said. “If they had told me not to drink, I wouldn’t have started in the first place — and it wouldn’t have spiraled into what it became.”

 

*Correction, Jan. 10, 2015: 

A previous version of this story identified Kenneth Blum by the incorrect profession. He is a neuroscientist.

Posted in: Life Science

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  1. I am a LCDC in Texas and at one point I did Utilization Review for two years and started to notice a trend. Many people were seeking treatment that had gastric bypass surgery or bariatric surgery. They and there families were adamant about them having no problems with alcohol prior to the surgery.
    My personal view relates the problem to the stomach and metabolism. I do not believe it is addiction transfer or it would happen with other drugs as well. But just like the article stated, it is really happening consistently with alcohol, not other drugs. The testimonies after the article say it all, this is a huge problem. I once heard a doctor give a lecture on how alcohol breaks down in the stomach and the theory that in natural born alcoholics they are missing some of the chemical processes that occur in the stomach consistent with what Dr. Silkworth called the “Craving”. People who drink their way into alcoholism damage their stomachs so that it does not process alcohol like a normal person and now we have a bypass issues that would mean the stomach is not going to be able to process alcohol like a normal stomach.
    It is just my theory. Not really grounded in research…. yet. But I recently went back to school and looking for my dissertation topic in case I really do make it all the way and this one keeps coming up for me.
    I am in recovery myself and it’s like I told a Pt. of mine once. It does not really matter how you arrived at this point, there are many paths to alcoholism as it is already a complicated disease, but you’re here and you can’t drink and expect to live at this rate. There is a solution if you want to stop drinking, and support, it’s in the 12-steps. The steps are not a program, they are a way of life, and you can’t go to a way of life, you have to live it. People seem to get that confused as well.
    I hope one day I can help on this topic with more than speculation. But I do wish everyone struggling with this new found problem since the surgery, that they find a safe harbor in the rooms of AA.
    Peace.

    Rebecca Rusche, October 8, 2017 at 10:16 pm
  2. I had gastric bypass December 2014. By April 2015 (a little over 4 months post op) I started drinking red wine. I liked the feeling but wine would no longer satisfy my cravings by the summer of 2015. During the summer I started out drinking Cosmopolitans, a lady’s drink and just about pure alcohol. By the end of summer I was consuming 1-2 pints of Jack Daniels per day. I have blacked out, been arrested, been committed in the psych ward by my children, said some of the most hurtful things to the people who loved me the most that I’m surprised they’ll still even talk to me. I got help several times but it’s always short-lived. The longest I’ve made it this past year without a drink is 30 days. As soon as I got my 30 day AA coin I had to celebrate with shots of Fireball which turned back into Bourbon bingeing. In the past 2 days I drank a gallon of Jack Daniels. I feel like crap, have constant pain in my stomach, both lower and upper, and my doctor said I am in early Stage 2 liver disease. How in the heck did it happen that fast? She said right now my liver can still heal so why do I feel compelled to push it to the very brink so that I can keep drinking. I feel sick without any alcohol in my system. It’s funny, I had this surgery to be healthy & look good and I’m probably the most unhealthy I’ve ever been. But, hey, at least I look good, right?!?!

    Tammy, October 17, 2017 at 4:52 pm
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